Your gut controls immunity, mood, nutrient absorption, and inflammation. Most people are destroying it daily and calling it normal. Here's how to fix it.
Your gut isn't just for digestion. It's where 70% of your immune system lives. It produces 90% of your serotonin. It has its own nervous system (the enteric nervous system) that communicates directly with your brain. When your gut lining breaks down — called "leaky gut" — inflammation enters your bloodstream and causes issues everywhere: brain fog, fatigue, skin problems, joint pain, hormonal imbalance. The gut is first.
Intestinal permeability is driven by tight junction degradation (claudin, occludin, zonulin) allowing LPS translocation into portal circulation. Dysbiosis shifts the Firmicutes/Bacteroidetes ratio, increases SCFA deficit (reduced butyrate from fewer Bifidobacterium), and upregulates inflammatory cytokines (IL-6, TNF-α). GLP-1 medications slow gastric emptying, alter GI motility, and change microbiome composition — creating unique gut challenges. Zinc carnosine stabilizes tight junctions; BPC-157 is perhaps the most potent gut mucosal healing compound known.
Most Overlooked: GLP-1 medications (semaglutide, tirzepatide) dramatically change gut function. Nausea, constipation, and GERD aren't just "side effects" — they're signals your gut lining and motility need active support. We have a full protocol for this.
Semaglutide and tirzepatide change your gut dramatically. Here's the complete protocol to protect your gut lining and manage every side effect.
The 4R protocol: Remove, Replace, Reinoculate, Repair. Full 12-week roadmap for healing intestinal permeability from the inside out.
The most underrated gut supplement. Stabilizes tight junctions, reduces ulcers, slashes GLP-1 nausea. Japanese hospitals have used it for decades.
How to actually build diversity in your gut flora. Fermented foods, prebiotics, specific strains, and why most probiotics are a waste of money.
The most powerful gut healing compound in the biohacker's toolkit. How to use it for IBD, SIBO, leaky gut, and post-antibiotic gut damage.
Small intestinal bacterial overgrowth is dramatically underdiagnosed. Testing, treatment (herbal and pharmaceutical), and the prokinetic protocol to prevent recurrence.
| Supplement | Primary Role | Dose | Timing | Priority |
|---|---|---|---|---|
| Zinc Carnosine | Tight junction repair, anti-ulcer | 75mg | Twice daily with meals | ★★★★★ |
| L-Glutamine | Enterocyte fuel, lining repair | 5–10g | On empty stomach | ★★★★★ |
| Collagen Peptides | Mucosal layer support | 20g | Morning | ★★★★☆ |
| Akkermansia muciniphila | Mucin layer, metabolic health | Per label | Before bed | ★★★★☆ |
| Lactobacillus rhamnosus GG | Barrier function, immunity | 10–50B CFU | Morning, fasted | ★★★★☆ |
| Tributyrin / Butyrate | Colonocyte fuel, inflammation | 300–600mg | With meals | ★★★★☆ |
| Digestive Enzymes | Nutrient extraction, bloat | Per label | Start of meal | ★★★☆☆ |
| Deglycyrrhizinated Licorice (DGL) | Mucosal protection, GERD | 380–760mg | 20 min before meals | ★★★☆☆ |
| BPC-157 (oral) | Gut mucosal healing | 250–500mcg | Fasted, away from food | ★★★★★ (if needed) |
GLP-1 gut issues, microbiome questions, supplement stacks — answered in The Daily Biohack newsletter.
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